Alzheimer’s disease (AD) is defined as a neurodegenerative disorder with an estimated survival rate of 3 to 9 years which presents degenerative and pathological symptoms, as well as a progressive decline of the cognitive state, such as language, memory, executive function and social deterioration. Its appearance and development is associated with depression and anxiety.
The maintained emotional stress is associated to the AD as a consequence of neuronal death, mainly due to the accumulation of beta-amyloid peptide and tau protein. Different studies show evidence that high level of chronic stress causes depression basically because of monoaminergic changes that are generated in various brain regions and the suppression of hippocampal neurogenesis. This neuronal degeneration could also affect the limbic structures associated with emotional regulation, which explains the appearance of anxiety in many patients.